Characterization of diffusion and duration of action of a new botulinum toxin type A formulation.

Characterization of diffusion and duration of action of a new botulinum toxin type A formulation.
Authors: Stone HF, Zhu Z, Thach TQ, Ruegg CL RT002, an injectable form of botulinum neurotoxin type A (BoNTA), comprised of a purified 150 kDa neurotoxin formulated in a novel formulation, is designed to limit the extent of diffusion and permit safe administration of longer acting doses. The aim of this study was to evaluate the degree of diffusion of RT002 in comparison to another commercially available BoNTA product, Botox(®) Cosmetic (OnabotulinumtoxinA, Allergan, Inc., Irvine, CA, USA), and establish the relative duration of effect for diffusion matched doses of the two BoNTA formulations using quantitative measurements in mice. Measurement of muscle paralysis by muscle force generation (MFG) in mice at the injected gastrocnemius muscles indicated that RT002 and Botox are equipot...

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Botox has always had a cosmetic reputation, but at times it is used as an injectable muscle relaxer. Basically, The Botulinum toxin (BoNT) operates by temporarily stopping muscles contracting and therefore reducing muscle tightness or spasm. However, after numerous clinical studies, it has been found that this means of treatment does not aid in neck pain relief at least. Scientists who reviewed nine trials involving a total of 503 participants have published their findings this week... (Source: Health News from Medical News Today)


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