Saturday, September 3, 2011

A uroguanylin-GUCY2C endocrine axis regulates feeding in mice

A uroguanylin-GUCY2C endocrine axis regulates feeding in mice
Intestinal enteroendocrine cells are critical to central regulation of caloric consumption, since they activate hypothalamic circuits that decrease appetite and thereby restrict meal size by secreting hormones in response to nutrients in the gut. Although guanylyl cyclase and downstream cGMP are essential regulators of centrally regulated feeding behavior in invertebrates, the role of this primordial signaling mechanism in mammalian appetite regulation has eluded definition. In intestinal epithelial cells, guanylyl cyclase 2C (GUCY2C) is a transmembrane receptor that makes cGMP in response to the paracrine hormones guanylin and uroguanylin, which regulate epithelial cell dynamics along the crypt-villus axis. Here, we show that silencing of GUCY2C in mice disrupts satiation, resulting in hy...

Cancer survivors can thrive on inner strength
Resilience key factor as cancer survivors thrive despite emotional, physical challenges. (Source: MayoClinic.com Full Feed)

Sutent + renal cell carcinoma a winning combination . . .
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Eine Faltenbehandlung Preisvergleich erfordert immer eine entsprechende Nachbehandlung und Nachsorge, zu denen ebenfalls eine Kontrolle durch den Arzt geh�rt.

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